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ICD-10 Diagnosis Codes for High Cholesterol and Familial Hypercholesterolemia (FH)

The ICD-10 is the acronym of the International Classification of Diseases, Tenth version. It is the classification and codification of diseases and a wide variety of signs, symptoms, abnormal findings, allegations, social circumstances, and causes.

The ICD was published by the World Health Organization. It is used at international level for statistical purposes related to morbidity and mortality, reimbursement systems and automatic decision support in medicine. This system is designed to promote international comparison of the collection, processing, classification and presentation of these statistics. The ICD-10 is the central classification of the WHO Family of International Classifications (WHO-FIC).


The ICD-10 list originates from the “List of causes of death”, the first edition of which was published by the International Institute of Statistics in 1893. The WHO took charge of it in 1948, the sixth edition, the first to include causes of morbidity. To date, the current list is the tenth, and WHO continues to work on it. ICD-10 was developed in 1992 and was intended to track mortality statistics. The WHO publishes minor annual updates and major updates every three years.

Subsequently, some countries have created their own ICD-10 code extensions. For example, Australia presented its first edition, the “ICD-10-AM” in 1998; Canada issued its version in 2000, the “ICD-10-CA”. Germany also has its own extension, the “ICD-10-GM”. In the USA, it the “ICD-10-CM” (CM for Clinical Modification), but the annex was also added with the procedure classification system or “ICD-10-PCS”.

Each health condition can be assigned to a category and receive a code of up to six characters in length (in X00.00 format). Each such category may include a group of similar diseases. Each health condition can be assigned to a category and receive a code of up to six characters in length (in X00.00 format). Each such category may include a group of similar diseases. Each health condition can be assigned to a category and receive a code of up to six characters in length (in X00.00 format). Each such category may include a group of similar diseases.


High cholesterol ICD-10 diagnosis codes

E78.00 for:

  • Hypercholesteremia or high (elevated) cholesterol
  • Hyperlipoproteinemia low-density-lipoprotein-type (LDL)

So, when total cholesterol is high the code is E78.00; when LDL is high the code is also E78.00.

E78.1 for:

  • Hypertriglyceridemia or high (elevated) triglycerides
  • Hyperlipoproteinemia very-low-density-lipoprotein-type (VLDL)

E78.2 for:

  • Mixed hyperlipidemia or high (elevated) cholesterol with high (elevated) triglycerides

E78.6 for:

  • High-density lipoprotein (HDL) deficiency or depressed (low) HDL cholesterol

Familial Hypercholesterolemia (FH) ICD-10 codes

Although FH is one of the most common life-threatening genetic diseases affecting all races and ethnicities, there was no specific diagnostic code to differentiate FH from other forms of hypercholesterolemia. It was E78.00. This did not encourage family screening. As we already know, patients with FH require early and more aggressive treatment, and family screening is essential for this early diagnosis and treatment.

The submission made in January 2014 by the FH Foundation and the National Lipid Association (NLA) for the National Center for Health Statistics included the Heterozygous and Homozygous FH diagnosis and family history of FH. In response to the submission of the FH Foundation, two ICD-10 codes for Familial Hypercholesterolemia have been approved and became effective on October 1, 2016.

  • E78.01 for Familial Hypercholesterolemia
  • Z83.42 for Family History of FH.
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